منابع مشابه
Antiserum to Leucocyte Lysosomes
Antisera to rabbit polymorph granules and to rabbit erythrocytes have been prepared in guinea pigs. Both antigranule and antierythrocyte sera are hemolytic and both exhibit striking cytotoxicity on leucocytes. The sequence of toxic events, as observed by phase contrast cinemicrophotography and electron microscopy, consists of explosive granule lysis, cell swelling, cytoplasmic liquifaction, and...
متن کاملSTUDIES ON LYSOSOMES V. The Effects of Streptolysins and Other Hemolytic Agents on Isolated Leucocyte Granules
Granules from rabbit peritoneal leucocytes were prepared in 0.3 ~ sucrose as an optically homogeneous suspension with the aid of heparin. Lysis of the granules in vitro was followed by measurement of decreases in the apparent absorbance of the suspensions at 520 m# and was accompanied by solubilization of beta-glucuronidase from the particles. Streptolysins O and S from hemolytic streptococci l...
متن کاملSTUDIES ON LYSOSOMES V. The Effects of Streptolysins and Other Hemolytic Agents on Isolated Leucocyte Granules
Granules from rabbit peritoneal leucocytes were prepared in 0.3 ~ sucrose as an optically homogeneous suspension with the aid of heparin. Lysis of the granules in vitro was followed by measurement of decreases in the apparent absorbance of the suspensions at 520 m# and was accompanied by solubilization of beta-glucuronidase from the particles. Streptolysins O and S from hemolytic streptococci l...
متن کاملDrug targeting to lysosomes.
1982). It is not clear how the rate of entry into lysosomes themselves is affected, but it may be retarded. The situation is even more obscure in the case of entry into lysosomes by autophagy. There are some indications of abnormalities in endogenous protein breakdown, and in perhaps of the lysosomal component thereof, in I-cell disease (Cockle & Dean, 1984). Similarly, Sameshima et al. (1981) ...
متن کاملLysosomes
I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1964
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.120.2.149